Pharmacokinetic Parameters of Ceftazidime 2 g IV q8h and 3 g Cl over 24 Hours in Patients With Normal Renal Function

Nicolau DP et al. Infect Dis Clin Pract 1999; 8:45

II (n = 11) Cl (n = 10)

Weight [kg] 69.9 ? 9.3 69.0 ? 13.7

Cmax [µg/mL] 105.3 ? 28.0 15.9 ? 4.5

Cmean [µg/mL] ... 15.3 ? 4.2

t1/2 [h] 1.9 ? 0.6 ...

AUC 0-24 [µg*h/mL] 651.7 ? 163.4 365.6 ? 104.7

ClT [mL/min] 162.8 ? 42.7 143.6 ? 30.1

Note: Normal renal function is defined as creatinine clearance ?50 mL/min.

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