Time above MIC for ?-lactams
Is the magnitude of the parameter required for efficacy the same in different animal species including humans? YES
Does the magnitude of the parameter vary with:
- the dosing regimen? NO
- different sites of infection (e.g. blood, lung, peritoneum, soft tissue)? NO
- different drugs within the same class? Penicillins less than cephalosporins; no difference within groups providing free, unbound drug levels are used
- different organisms including resistant strains? FOR SOME; no difference for penicillin-resistant pneumococci
Craig. Diagn Microbiol Infect Dis 1996; 25:213–217
Craig. Clin Infect Dis 1998; 26:1–12
Craig. Ear Nose Throat J 1998; 77:7–11